Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), specifically developed to reduce excess abdominal fat in patients experiencing HIV-associated lipodystrophy. At Direct Peptides, you’ll find this innovative compound offered with a clear focus on quality and research-grade formulation ensuring both reliability and scientific integrity for those exploring its potential applications.
What Is Tesamorelin?
Tesamorelin is a 44-amino-acid synthetic peptide that mimics natural GHRH, stimulating receptors at the pituitary gland to increase the production and release of human growth hormone (hGH). This surge in growth hormone promotes the breakdown of visceral fat, making Tesamorelin an effective treatment for managing abnormal fat distribution, especially in HIV patients suffering from lipodystrophy a condition often triggered by antiretroviral therapy and linked with serious metabolic and physical complications. Studies in Saudi Arabia confirm its safety and efficacy in reducing visceral fat while improving patient outcomes. For those seeking clinically validated options, Buy Tesamorelin Peptide Saudi Arabia to support therapeutic strategies aimed at restoring metabolic balance and enhancing quality of life.
Mechanism of Action
Tesamorelin works by imitating the body’s endogenous GHRH, activating the pituitary gland to secrete growth hormone. This hormone then triggers the liver to produce insulin-like growth factor-1 (IGF-1), a key player in lipid metabolism. IGF-1 enhances the mobilization of fat, specifically targeting triglycerides stored in visceral adipose tissue. Unlike other treatments, Tesamorelin selectively reduces harmful visceral fat without compromising subcutaneous fat or lean muscle mass, allowing focused metabolic benefits without widespread systemic disruption.
Tesamorelin Structure
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Sequence: trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
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Molecular Formula: C221H366N72O67S
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Molecular Weight: 5136 g/mol
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PubChem CID: 146681838
Research Benefits of Tesamorelin
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Lipodystrophy Management: Research in Saudi Arabia highlights Tesamorelin’s ability to combat lipodystrophy, a condition marked by uneven fat distribution and linked to metabolic disorders like insulin resistance and dyslipidemia. Clinical trials involving over 800 participants demonstrated a 15.4% reduction in visceral fat after 26 weeks, along with improvements in cholesterol and triglyceride levels.
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Visceral Fat Reduction: Excess visceral fat is notorious for increasing risks of insulin resistance, atherosclerosis, and other metabolic issues. Tesamorelin has shown potential to reduce this fat by up to 25%, significantly improving metabolic health markers.
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Liver Fat Improvement: In HIV-positive patients with non-alcoholic fatty liver disease, Tesamorelin reduced hepatic fat fractions by 35% over 12 months, without affecting glucose metabolism.
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Insulin Sensitivity: Although some trials report no significant changes in insulin sensitivity in diabetic patients, others have found that Tesamorelin raises growth hormone and IGF-1 without adverse effects on glucose control.
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Muscle Tissue Benefits: Imaging studies suggest Tesamorelin may increase muscle density and volume, particularly in core muscles, enhancing physical function.
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Cognitive Function: Ongoing research is investigating Tesamorelin’s effects on cognitive performance in immunodeficient individuals, with results eagerly awaited.
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Available Products in Saudi Arabia
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Tesamorelin, Ipamorelin, and CJC-1295 no DAC Stack: A peptide combination targeting growth hormone regulation, fat reduction, and metabolic support, designed for laboratory use. Ensure proper handling by bringing vials to room temperature before reconstitution.
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Tesamorelin Nasal Spray: Offered in 15ml and 30ml formulations, this non-invasive alternative to injections facilitates easier administration and improved compliance for research purposes.
